N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide

Base Information

Chemical Name:N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide
CAS No.:1610801-28-9
Molecular Formula:C₂₇H₃₇N₃O₃Si
Molecular Weight:479.695
Hs Code.:

Synonyms:N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide

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Chemical Property of N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide

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Technology Process of N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide

There total 1 articles about N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610801-24-5
N-(5-bromo-1H-indol-7-yl)cyclopropanecarboxamide

: 1610801-28-9
N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(I) bromide; potassium carbonate; sodium hydroxide; copper diacetate / toluene / 6.17 h / 100 °C

2: palladium diacetate; caesium carbonate; 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl / toluene / 7 h / 100 °C / Inert atmosphere

With 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl; copper diacetate; palladium diacetate; potassium carbonate; caesium carbonate; copper(I) bromide; sodium hydroxide; In toluene;

Reference yield: 85.0%

: 1610801-28-9
N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide

: 87600-97-3
4,6-dichloropyrimidine-5-carboxylic acid chloride

: 1610801-30-3
N-(2-(tert-butyldimethylsilyloxy)ethyl)-4,6-dichloro-N-(7-(cyclopropanecarboxamido)-1-(2-methoxyphenyl)-1H-indol-5-yl)pyrimidine-5-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; for 2h; Cooling with ice;

Reference yield:

: 1610801-28-9
N-(5-(2-(tert-butyldimethylsilyloxy)ethylamino)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide

: 1610800-27-5
N-(5-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-1-(2-methoxyphenyl)-1H-indol-7-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / Cooling with ice

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

3: triethylamine / acetonitrile / 3 h / 80 °C

4: ammonia / 1,4-dioxane / 2 h / 20 °C

With tetrabutyl ammonium fluoride; ammonia; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;