methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate

Base Information

Chemical Name:methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate
CAS No.:124287-86-1
Molecular Formula:C₁₁H₁₆ClNO₄
Molecular Weight:261.705
Hs Code.:

methyl (1R,2S,5R)-5-chloro-2-<N-methyl(methoxycarbonyl)amino>cyclohex-3-enecarboxylate

Synonyms:methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate

Suppliers and Price of methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate

There total 6 articles about methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 111515-78-7
methyl (1R,2S,5S)-5-hydroxy-2-cyclohex-3-enecarboxylate

: 124287-86-1
methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate

Guidance literature:: With methanesulfonyl chloride; triethylamine; In 1,2-dichloro-ethane; for 96h; Ambient temperature;
DOI:10.1021/jo00291a014

Reference yield:

: 124287-84-9
(1R,6S)-6-<(methoxycarbonyl)amino>cyclohex-3-enecarboxylic acid

: 124287-86-1
methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / I₂, KI, NaHCO₃ / CH₂Cl₂; H₂O / 20 h / Ambient temperature

2: 94 percent / DBU / benzene / 3 h / Heating

3: 95 percent / Ag₂O / dimethylformamide / 48 h / Ambient temperature

4: 99 percent / methanol / 1 h / 0 °C

5: 76 percent / methanesulfonyl chloride, triethylamine / 1,2-dichloro-ethane / 96 h / Ambient temperature

With iodine; sodium hydrogencarbonate; methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium iodide; silver(l) oxide; In methanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00291a014

Reference yield:

: 111515-77-6
(1R,2S,5S)-2-<(methoxycarbonyl)amino>-7-oxo-6-oxabicyclo<3.2.1>oct-3-ene

: 124287-86-1
methyl (1R,2S,5R)-5-chloro-2-cyclohex-3-enecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Ag₂O / dimethylformamide / 48 h / Ambient temperature

2: 99 percent / methanol / 1 h / 0 °C

3: 76 percent / methanesulfonyl chloride, triethylamine / 1,2-dichloro-ethane / 96 h / Ambient temperature

With methanesulfonyl chloride; triethylamine; silver(l) oxide; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00291a014