4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol

Base Information

• Chemical Name: 4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol
• CAS No.: 934736-12-6
• Molecular Formula: C₁₈H₂₁N₃O
• Molecular Weight: 295.384
• Mol file: 934736-12-6.mol

Synonyms:4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol

Chemical Property of 4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol

There total 5 articles about 4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C18H19NO2 (906106-99-8) → 4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol (934736-12-6)

Guidance literature:

With thionyl chloride; hydrazine hydrate; In diethyl ether; at 60 ℃; for 0.5h;

DOI:10.4314/bcse.v28i2.11

Reference yield:

1-(4-hydroxy-3-methylphenyl)-3-(4-dimethylaminophenyl)-2-propen-1-one → 4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol (934736-12-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 7h; Heating;

DOI:10.1016/j.ejmech.2006.08.004 DOI:10.1002/jccs.200700014

Reference yield:

4-hydroxy-3-methylphenyl methyl ketone (876-02-8) → 4-[5-(4'-dimethylaminophenyl)-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol (934736-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / ethanol; petroleum ether / 4 h

2: hydrazine hydrate / ethanol / 7 h / Heating

With sodium hydroxide; hydrazine hydrate; In ethanol; Petroleum ether; 1: Claisen-Schmidt condensation;

DOI:10.1002/jccs.200700014

upstream raw materials:

4-hydroxy-3-methylphenyl methyl ketone

4-dimethylamino-benzaldehyde

C₁₈H₁₉NO₂