N²-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine

Base Information

• Chemical Name: N²-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine
• CAS No.: 141437-72-1
• Molecular Formula: C₃₄H₃₈N₄O₇
• Molecular Weight: 614.698

Synonyms:N²-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine

Chemical Property of N²-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of N²-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine

There total 5 articles about N²-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine (133648-45-0) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → N2-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine (141437-72-1)

Guidance literature:

In N,N-dimethyl-formamide; for 5h; Ambient temperature;

DOI:10.1021/jo00037a048

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → N2-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine (141437-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / pyridine / 18 h / Ambient temperature

2: 62 percent / 1.) NaOEt / 1.) EtOH, r. t., 20 min, 2.) reflux, 30 min

3: 100 percent / dimethylformamide / 5 h / Ambient temperature

With pyridine; sodium ethanolate; In N,N-dimethyl-formamide;

DOI:10.1021/jo00037a048

Reference yield:

1,3,2'-O-trimethyl-5'-O-(dimethoxytrityl)pseudouridine (141411-20-3) → N2-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine (141437-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / 1.) NaOEt / 1.) EtOH, r. t., 20 min, 2.) reflux, 30 min

2: 100 percent / dimethylformamide / 5 h / Ambient temperature

With sodium ethanolate; In N,N-dimethyl-formamide;

DOI:10.1021/jo00037a048

upstream raw materials:

2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine

N,N-dimethyl-formamide dimethyl acetal

4,4'-dimethoxytrityl chloride

1,3,2'-O-trimethylpseudouridine

Downstream raw materials:

N²-<(dimethylamino)methylene>-2'-O-methyl-5'-O-(dimethoxytrityl)pseudoisocytidine 3'-N,N-diisopropylphosphoramidite

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