methyl (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetate

Base Information

• Chemical Name: methyl (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetate
• CAS No.: 861448-72-8
• Molecular Formula: C₃₄H₄₈N₂O₆SSi
• Molecular Weight: 640.916

Synonyms:methyl (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetate

Chemical Property of methyl (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetate

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Technology Process of methyl (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetate

There total 1 articles about methyl (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

methyl {3-[(2R)-2-aminopropyl]phenyl}acetate (792917-97-6) + N-[2-(benzyloxy)-5-((1R)-2-bromo-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenyl]methane sulfonamide (861448-71-7) → methyl (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetate (861448-72-8)

Guidance literature:

In dichloromethane; at 90 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm1005989

Reference yield: 90.0%

methyl (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetate (861448-72-8) → (3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetic acid (861448-84-2)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jm1005989

upstream raw materials:

methyl {3-[(2R)-2-aminopropyl]phenyl}acetate

N-[2-(benzyloxy)-5-((1R)-2-bromo-1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenyl]methane sulfonamide

Downstream raw materials:

(3-{(2R)-2-[((2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-{[tert-butyl-(dimethyl)silyl]oxy}ethyl)amino]propyl}phenyl)acetic acid

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