N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide

Base Information

Chemical Name:N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide
CAS No.:1264366-93-9
Molecular Formula:C₂₄H₂₂N₂O₄
Molecular Weight:402.45
Hs Code.:

Synonyms:N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide

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Chemical Property of N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide

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Technology Process of N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide

There total 6 articles about N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1264366-82-6
N-{[2-(4-benzyloxy)phenyl]ethyl}-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide

: 1264366-93-9
N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; dichloromethane; at 20 ℃; for 22h;
DOI:10.1002/ejoc.201001077

Reference yield:

: 51-67-2
tyrosamine

: 1264366-93-9
N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 31 h / Reflux

2: potassium carbonate / acetone / 12 h / Reflux

3: triethylamine; trichlorophosphate / dichloromethane / 2.25 h / -30 °C / Inert atmosphere

4: isopropyl alcohol / 48 h / 20 °C / Molecular sieve; Inert atmosphere

5: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / ethanol; dichloromethane / 22 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; trichlorophosphate; In ethanol; dichloromethane; isopropyl alcohol; acetone; toluene; 4: Ugi condensation / 5: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077

Reference yield:

: 1264366-68-8
C₃₁H₃₀N₂O₅

: 1264366-93-9
N-[2-(4-hydroxyphenyl)ethyl]-2-{3-oxo-2H-benzo[b][1,4]oxazin-4(3H)-yl}-2-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / dichloromethane; toluene / 1 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol; dichloromethane / 22 h / 20 °C

With palladium 10% on activated carbon; hydrogen; triphenylphosphine; diethylazodicarboxylate; In ethanol; dichloromethane; toluene; 1: Mitsunobu reaction;
DOI:10.1002/ejoc.201001077