(5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Base Information

Chemical Name:(5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate
CAS No.:1544740-25-1
Molecular Formula:C₃₃H₃₆F₂N₂O₄
Molecular Weight:562.657
Hs Code.:

(5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Synonyms:(5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

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Chemical Property of (5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

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Technology Process of (5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

There total 5 articles about (5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1544740-24-0
1-(3-(4-bromo-3,5-dimethylphenoxy)propyl)-3,3-difluoroazetidine

: 1544739-26-5
(5aR,6S,6aS)-ethyl 3-((3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

: 1544740-25-1
(5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In tetrahydrofuran; water; at 100 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1544739-39-0
methyl 3-(4-bromo-3,5-dimethylphenoxy)propanoate

: 1544740-25-1
(5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / methanol / 2 h / 100 °C

2.1: triethylamine / N,N-dimethyl-formamide / 0.25 h

2.2: 40 °C

3.1: borane-THF / tetrahydrofuran / 10 h / Reflux

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / tetrahydrofuran; water / 0.5 h / 100 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; borane-THF; water; triethylamine; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 938294-53-2
3-(4-bromo-3,5-dimethylphenoxy)propanoic acid

: 1544740-25-1
(5aR,6S,6aS)-ethyl 3-((4’-(3-(3,3-difluoroazetidin-1-yl)propoxy)-2’,6’-dimethyl-[1,1’-biphenyl]-3-yl)methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.25 h

1.2: 40 °C

2.1: borane-THF / tetrahydrofuran / 10 h / Reflux

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / tetrahydrofuran; water / 0.5 h / 100 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; borane-THF; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;