phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

Base Information

• Chemical Name: phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate
• CAS No.: 1044574-39-1
• Molecular Formula: C₂₁H₂₀Cl₂N₂O₄
• Molecular Weight: 435.307

Synonyms:phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

Chemical Property of phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

Chemical Property:

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Technology Process of phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate

There total 1 articles about phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

bis(trichloromethyl) carbonate (32315-10-9) + phenylmethyl 4-{[(3,4-dichlorophenyl)amino]methyl}-4-hydroxy-1-piperidinecarboxylate (1044574-40-4) → phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate (1044574-39-1)

Guidance literature:

With triethylamine; In dichloromethane; at 5 - 20 ℃; for 1.83333h;

Reference yield:

phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate (1044574-39-1) → 3-(3,4-dichlorophenyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one (1044574-38-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methylated spirits; for 6h; under 2585.81 Torr;

Reference yield:

phenylmethyl 3-(3,4-dichlorophenyl)-2-oxo-1-oxa-3,8-diazaspiro[4.5]decane-8-carboxylate (1044574-39-1) → 3-(3,4-dichlorophenyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrobromide (1073559-54-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In industrial methylated spirits; for 6h; under 2585.81 Torr;

upstream raw materials:

bis(trichloromethyl) carbonate

phenylmethyl 4-{[(3,4-dichlorophenyl)amino]methyl}-4-hydroxy-1-piperidinecarboxylate

Downstream raw materials:

3-(3,4-dichlorophenyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

3-(3,4-dichlorophenyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrobromide

3-(3,4-dichlorophenyl)-8-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1-oxa-3,8-diazaspiro-[4.5]decan-2-one

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