3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester

Base Information

• Chemical Name: 3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester
• CAS No.: 883564-50-9
• Molecular Formula: C₁₆H₁₇Br₂NO₂
• Molecular Weight: 415.124
• Mol file: 883564-50-9.mol

Synonyms:3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester

Chemical Property of 3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester

There total 2 articles about 3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

2,5-bis(bromomethyl)benzyl alcohol + N-(2-carboxyethyl)pyrrole (89059-06-3) → 3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester (883564-50-9)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ol0602553

Reference yield:

2,5-bis(bromomethyl)benzoate (148692-73-3) → 3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester (883564-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / diisobutylaluminum hydride / toluene / 3 h / 0 °C

2: 69 percent / 1,3-dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 3 h / 20 °C

With dmap; diisobutylaluminium hydride; dicyclohexyl-carbodiimide; In dichloromethane; toluene;

DOI:10.1021/ol0602553

Reference yield: 92.0%

3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester (883564-50-9) + 1-methyl-4-(4-pyridyl)pyridinium iodide (38873-01-7) → C38H39N5O2(4+)*4F6P(1-)

Guidance literature:

3-pyrrol-1-yl-propionic acid 2,5-bis-bromomethyl-benzyl ester; 1-methyl-4-(4-pyridyl)pyridinium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 3h;

With ammonium hexafluorophosphate; In water;

DOI:10.1021/ol0602553

upstream raw materials:

N-(2-carboxyethyl)pyrrole

2,5-bis(bromomethyl)benzoate