Technology Process of (3-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-propyl)-dimethyl-amine
There total 9 articles about (3-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-propyl)-dimethyl-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
methanol;
at 20 ℃;
under 2585.81 Torr;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 0.67 h / 110 °C / Inert atmosphere; Microwave irradiation
2: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr
With
hydrogen; potassium carbonate;
palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C
2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C
3.1: potassium carbonate; tetraethylammonium chloride / triphenylphosphine; palladium diacetate / acetonitrile / 3 h / 80 °C / Inert atmosphere
4.1: N-Bromosuccinimide; acetic acid / dichloromethane / 0 - 5 °C
5.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C
5.2: -78 °C
6.1: N-ethyl-N,N-diisopropylamine; ammonium chloride; HATU / N,N-dimethyl-formamide / 20 °C
7.1: toluene / 2 h / 90 °C
7.2: 2 h / 90 °C
8.1: potassium carbonate / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 0.67 h / 110 °C / Inert atmosphere; Microwave irradiation
9.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr
With
N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; tetraethylammonium chloride; hydrogen; potassium carbonate; ammonium chloride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU;
palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triphenylphosphine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
![(3-{2-[2-(2,4-Difluoro-phenyl)-2H-[1,2,4]triazol-3-yl]-4,5-dihydro-6-oxa-1-thia-10-aza-benzo[e]azulen-9-yl}-prop-2-ynyl)-dimethyl-amine](/Databaselist/images/loading.webp)
