1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine

Base Information

• Chemical Name: 1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine
• CAS No.: 1005484-25-2
• Molecular Formula: C₁₅H₂₅N₅O₂
• Molecular Weight: 307.396
• Mol file: 1005484-25-2.mol

Synonyms:1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine

Chemical Property of 1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine

There total 10 articles about 1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,4-di-tert-butyl 7-(2-{[(tert-butoxy)carbonyl]amino}-3-(4-nitrophenyl)propyl)-1,4,7-triazonane-1,4-dicarboxylate (1005484-24-1) → 1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine (1005484-25-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 16h;

DOI:10.1002/ejoc.201301499

Reference yield: 68.0%

N-(1-{4,7-bis[(4-methylphenyl)sulfonyl]-1,4,7-triazonan-1-yl}-3-(4-nitrophenyl)propan-2-yl)-4-methylbenzene-1-sulfonamide (1353022-72-6) → 1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine (1005484-25-2)

Guidance literature:

With sulfuric acid; at 115 ℃; for 72h;

DOI:10.1002/ejoc.201101063

Reference yield:

tert-butyl N-[1-(4-nitrophenyl)-3-oxopropan-2-yl]carbamate (1258945-86-6) → 1-(4-nitrobenzyl)-2-(1,4,7-triazacyclononan-1-yl)ethylamine (1005484-25-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 24 h / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; sodium tris(acetoxy)borohydride; In 1,4-dioxane; 1,2-dichloro-ethane;

DOI:10.1002/ejoc.201301499

upstream raw materials:

1,4-di-tert-butyl 7-(2-{[(tert-butoxy)carbonyl]amino}-3-(4-nitrophenyl)propyl)-1,4,7-triazonane-1,4-dicarboxylate

2-[(4-methylphenyl)sulfonamido]-3-(4-nitrophenyl)propanamide

N-[1-amino-3-(4-nitrophenyl)propan-2-yl]-4-methylbenzene-1-sulfonamide

tert-butyl N-[1-(4-nitrophenyl)-3-oxopropan-2-yl]carbamate

Downstream raw materials:

{4-carboxymethyl-7-[2-(carboxymethyl-amino)-3-(4-isothiocyanato-phenyl)-propyl]-[1,4,7]-triazonan-1-yl}-acetic acid

2-[(1-{4-[(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-5-amino-9,16-dihydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]pentanamido]phenyl}-3-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]propan-2-yl)amino]acetic acid

2-({1-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]-3-{4-[(4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R,16S)-9,16-dihydroxy-2,15-dimethyl-5-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]tetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]pentanamido]phenyl}propan-2-yl}amino)acetic acid

[4-carboxymethyl-7-(2-(carboxymethyl-amino)-3-{4-[(R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoylamino]phenyl}-propyl)-[1,4,7]triazonan-1-yl]-acetic acid