(R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

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Chemical Name:(R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate
CAS No.:1426836-28-3
Molecular Formula:C₃₇H₄₈N₆O₄Si
Molecular Weight:668.911
Hs Code.:

(R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

Synonyms:(R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

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Technology Process of (R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

There total 5 articles about (R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1007882-12-3
(S)-tert-butyl 2-(5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1334313-75-5
(R)-tert-butyl 5-(5-(4-bromophenyl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

: 1426836-28-3
(R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; for 6h; Inert atmosphere; Reflux;

Reference yield:

: 268224-27-7
(R)-1-tert-butyl-5-methyl 3,3-dimethyl-1,3-azasilolidine-1,5-dicarboxylate

: 1426836-28-3
(R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: water; potassium hydroxide / methanol / 15 h / 20 °C

2: triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

3: ammonium acetate / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 120 °C

4: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; water; sodium carbonate; triethylamine; potassium hydroxide; In 1,4-dioxane; methanol; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;

Reference yield:

: 268224-19-7
(2R,5R)-2-(((iodomethyl)dimethylsilyl)methyl)-5-isopropyl-3,6-dimethoxy-2,5-dihydropyrazine

: 1426836-28-3
(R)-tert-butyl 5-(5-(4'-(2-((S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)-1H-imidazol-2-yl)-3,3-dimethyl-1,3-azasilolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water; methanol / 5 h / 20 °C

1.2: 7 h / 20 °C

1.3: 15 h / 20 °C

2.1: water; potassium hydroxide / methanol / 15 h / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 15 h / 20 °C

4.1: ammonium acetate / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 120 °C

5.1: sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 6 h / Inert atmosphere; Reflux

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ammonium acetate; water; sodium carbonate; triethylamine; potassium hydroxide; In 1,4-dioxane; methanol; 5,5-dimethyl-1,3-cyclohexadiene; water; N,N-dimethyl-formamide;