Spiro[bicyclo[3.1.0]hexane-6,2-[1,3]dioxolane], 2-methyl-, [1R-(1-alpha-,2-bta-,5-alpha-)]- (9CI)

Base Information

• Chemical Name: Spiro[bicyclo[3.1.0]hexane-6,2-[1,3]dioxolane], 2-methyl-, [1R-(1-alpha-,2-bta-,5-alpha-)]- (9CI)
• CAS No.: 117465-62-0
• Molecular Formula: C₉H₁₄O₂
• Molecular Weight: 154.209
• Mol file: 117465-62-0.mol

Synonyms:Spiro[bicyclo[3.1.0]hexane-6,2-[1,3]dioxolane], 2-methyl-, [1R-(1-alpha-,2-bta-,5-alpha-)]- (9CI)

Chemical Property of Spiro[bicyclo[3.1.0]hexane-6,2-[1,3]dioxolane], 2-methyl-, [1R-(1-alpha-,2-bta-,5-alpha-)]- (9CI)

Chemical Property:

• Boiling Point: 195.4±8.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Spiro[bicyclo[3.1.0]hexane-6,2-[1,3]dioxolane], 2-methyl-, [1R-(1-alpha-,2-bta-,5-alpha-)]- (9CI)

There total 7 articles about Spiro[bicyclo[3.1.0]hexane-6,2-[1,3]dioxolane], 2-methyl-, [1R-(1-alpha-,2-bta-,5-alpha-)]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(-)-(3R)-7-methyl-6,10-dibromo-1,4-dioxaspiro<4.5>decane → (+)-(1R,2R,5S)-2-endo-methylspiro1,5>hexane-6,2'-<1',3'>dioxolane> (117465-67-5,117465-62-0)

Guidance literature:

With iodine; magnesium; In tetrahydrofuran; 1.) 40 deg C, 10 min, 2.) reflux, 2 h;

DOI:10.1021/ja00233a029

Reference yield:

(-)-spiro<6-methylenebicyclo<3.1.01,5>hex-3-ene-2,2'-<1',3'>dioxolane> → C9H12O2 + C9H14O2 + C9H14O2 (117465-67-5,117465-62-0) + (+)-(1R,2R,5S)-2-endo-methylspiro1,5>hexane-6,2'-<1',3'>dioxolane> (117465-67-5,117465-62-0)

Guidance literature:

With dihydrogen peroxide; hydrazine hydrate; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given; 1.) benzene-d6, 88.1 deg C, 1460 min, 2.) benzene-d6/ethanol/THF, 0 deg C, 2 h;

DOI:10.1021/ja00233a029

Reference yield:

(-)-spiro<6-methylenebicyclo<3.1.01,5>hex-3-ene-2,2'-<1',3'>dioxolane> → C9H12O2 + C9H14O2 + C9H14O2 (117465-67-5,117465-62-0) + (+)-(1R,2R,5S)-2-endo-methylspiro1,5>hexane-6,2'-<1',3'>dioxolane> (117465-67-5,117465-62-0)

Guidance literature:

With dihydrogen peroxide; hydrazine hydrate; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given; 1.) benzene-d6, 88.1 deg C, 1460 min, 2.) benzene-d6/ethanol/THF, 0 deg C, 2 h;

DOI:10.1021/ja00233a029

upstream raw materials:

(3R)-3-methylcyclohexanone

(-)-(R)-7-methyl-1,4-dioxaspiro<4.5>decane