5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide

Base Information

Chemical Name:5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide
CAS No.:155955-18-3
Molecular Formula:C₁₂H₁₀F₃NO₃S₂
Molecular Weight:337.344
Hs Code.:

Synonyms:5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide

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Chemical Property of 5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide

Chemical Property:

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Technology Process of 5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide

There total 6 articles about 5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025809-52-2
5-[(3-Trifluoromethyl-phenyl)-trimethylsilanyloxy-methyl]-thiophene-3-sulfonic acid amide

: 155955-18-3
5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.333333h;
DOI:10.1016/0223-5234(96)89133-1

Reference yield:

: 18791-75-8
4-Bromothiophen-2-aldehyde

: 155955-18-3
5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: cyclohexane; diethyl ether; tetrahydrofuran / 2.5 h / -78 °C

2: cyclohexane; diethyl ether; tetrahydrofuran / 0.5 h

3: 1.) n-BuLi, 2.) SO₂, 3.) N-chlorosuccinimide

4: NH₄OH / acetone / 0.25 h

5: tetra-n-butylammonium fluoride / tetrahydrofuran / 0.33 h

With ammonium hydroxide; N-chloro-succinimide; n-butyllithium; sulfur dioxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; cyclohexane; acetone;
DOI:10.1016/0223-5234(96)89133-1

Reference yield:

: 368-49-0
3-(trifluoromethyl)phenyllithium

: 155955-18-3
5-<1-hydroxy-1-(3-trifluoromethylphenyl)methyl>-3-thiophenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: cyclohexane; diethyl ether; tetrahydrofuran / 2.5 h / -78 °C

2: cyclohexane; diethyl ether; tetrahydrofuran / 0.5 h

3: 1.) n-BuLi, 2.) SO₂, 3.) N-chlorosuccinimide

4: NH₄OH / acetone / 0.25 h

5: tetra-n-butylammonium fluoride / tetrahydrofuran / 0.33 h

With ammonium hydroxide; N-chloro-succinimide; n-butyllithium; sulfur dioxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; diethyl ether; cyclohexane; acetone;
DOI:10.1016/0223-5234(96)89133-1