(E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate

Base Information

Chemical Name:(E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate
CAS No.:1353024-60-8
Molecular Formula:C₂₅H₂₇NO₅S
Molecular Weight:453.559
Hs Code.:

Synonyms:(E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate

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Chemical Property of (E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate

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Technology Process of (E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate

There total 7 articles about (E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1353024-64-2
(E)-4-(N-(4-hydroxyhex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate

: 1353024-60-8
(E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1002/anie.201104028

Reference yield:

: 4-((methylsulfonyl)oxy)but-2-yn-1-yl 4-methylbenzoate

: 1353024-60-8
(E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium iodide / acetone / 3 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetone / 4 h / 70 °C / Inert atmosphere

3: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

4: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With di-isopropyl azodicarboxylate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triphenylphosphine; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1002/anie.201104028

Reference yield:

: 1353024-61-9
C₁₂H₁₂O₃

: 1353024-60-8
(E)-4-(4-methyl-N-(4-oxohex-2-en-1-yl)-4-methylphenylsulfonamido)but-2-yn-1-yl 4-methyl-benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 3 h / 20 °C / Inert atmosphere

2: sodium iodide / acetone / 3 h / 20 °C / Inert atmosphere

3: potassium carbonate / acetone / 4 h / 70 °C / Inert atmosphere

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

5: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2 h / 20 °C

With di-isopropyl azodicarboxylate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; triphenylphosphine; sodium iodide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1002/anie.201104028