C₁₆H₂₀O₂

Base Information

• Chemical Name: C₁₆H₂₀O₂
• CAS No.: 1331831-78-7
• Molecular Formula: C₁₆H₂₀O₂
• Molecular Weight: 244.334
• Mol file: 1331831-78-7.mol

Synonyms:C₁₆H₂₀O₂

Chemical Property of C₁₆H₂₀O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₀O₂

There total 1 articles about C₁₆H₂₀O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

p-Methoxybenzyl bromide (2746-25-0) + oct-7-en-1-yn-4-ol (79937-96-5) → C16H20O2 (1331831-78-7)

Guidance literature:

oct-7-en-1-yn-4-ol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 23 ℃; for 1.16667h; Inert atmosphere;

p-Methoxybenzyl bromide; In tetrahydrofuran; mineral oil; at 0 - 23 ℃; for 18.1667h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.06.114

Reference yield: 67.0%

C16H20O2 (1331831-78-7) + N-Methoxy-N-methylacetamide (78191-00-1) → 6-(4-methoxyphenylmethoxy)dec-9-en-3-yn-2-one (1331831-77-6)

Guidance literature:

C₁₆H₂₀O₂; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h; Inert atmosphere;

N-Methoxy-N-methylacetamide; In tetrahydrofuran; hexane; at -78 - 23 ℃; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.06.114

Reference yield:

C16H20O2 (1331831-78-7) → C32H48O6Si

Guidance literature:

Multi-step reaction with 7 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C / Inert atmosphere

1.2: -78 - 23 °C / Inert atmosphere

2.1: Grubbs catalyst first generation / benzene / 1 h / 23 °C / Inert atmosphere

3.1: methylaluminum dichloride / dichloromethane; toluene / 0.75 h / -78 °C / Inert atmosphere

4.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tetrahydrofuran; tert-butyl alcohol / 15 h / 23 °C

5.1: pyridine; dmap / dichloromethane / 0.58 h / 0 °C / Inert atmosphere

6.1: Dess-Martin periodane / dichloromethane / 2 h / 23 °C / Inert atmosphere

7.1: water; potassium carbonate / methanol / 1 h / 23 °C

With pyridine; Grubbs catalyst first generation; dmap; osmium(VIII) oxide; n-butyllithium; water; methylaluminum dichloride; potassium carbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; hexane; dichloromethane; toluene; tert-butyl alcohol; benzene; 3.1: Diels-Alder reaction;

DOI:10.1016/j.tetlet.2011.06.114

upstream raw materials:

p-Methoxybenzyl bromide

oct-7-en-1-yn-4-ol

Downstream raw materials:

3-(5-(4-methoxyphenylmethoxy)cyclohex-1-enyl)but-3-en-2-one

6-(4-methoxyphenylmethoxy)dec-9-en-3-yn-2-one