5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol

Base Information

• Chemical Name: 5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol
• CAS No.: 797786-45-9
• Molecular Formula: C₁₇H₁₁BrFN₅O
• Molecular Weight: 400.21

Synonyms:5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol

Chemical Property of 5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol

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Technology Process of 5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol

There total 1 articles about 5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

5-bromo-8-hydroxy-1,6-naphthyridine-7-carbonitrile (797788-21-7) + 4-fluorophenylacetic acid hydrazide (34547-28-9) → 5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol (797786-45-9)

Guidance literature:

5-bromo-8-hydroxy-1,6-naphthyridine-7-carbonitrile; 4-fluorophenylacetic acid hydrazide; In 1,4-dioxane; acetic acid; at 200 ℃; for 0.166667h; Microwave chamber;

With sodium hydroxide; In water; ethyl acetate; pH=5; Acidic conditions;

Reference yield: 67.0%

2-Ketopiperazine (5625-67-2) + 5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol (797786-45-9) → 4-{7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-8-hydroxy-[1,6]naphthyridin-5-yl}-piperazin-2-one

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 18h;

Reference yield: 50.0%

1-methyl-piperazine (109-01-3) + 5-bromo-7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-[1,6]naphthyridin-8-ol (797786-45-9) → 7-[5-(4-fluoro-benzyl)-4H-[1,2,4]triazol-3-yl]-5-(4-methyl-piperazin-1-yl)-[1,6]naphthyridin-8-ol

Guidance literature:

at 150 ℃; for 16h;

upstream raw materials:

5-bromo-8-hydroxy-1,6-naphthyridine-7-carbonitrile

4-fluorophenylacetic acid hydrazide

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