(1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: (1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester
• CAS No.: 151103-60-5
• Molecular Formula: C₁₆H₂₄N₂O₄
• Molecular Weight: 308.378
• Mol file: 151103-60-5.mol

Synonyms:(1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester

Chemical Property of (1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester

There total 1 articles about (1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(1'R,2'S)-N-<4-ethoxy-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester → (1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester (151103-60-5)

Guidance literature:

With ammonia; In methanol; for 72h; Ambient temperature;

DOI:10.1021/jm00073a012

Reference yield:

(1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester (151103-60-5) → (3S,4R)-4-Amino-3-hydroxy-5-phenyl-pentanoic acid amide; hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 2h; Ambient temperature;

DOI:10.1021/jm00073a012

Reference yield:

(1'R,2'S)-N-<4-amino-2-hydroxy-4-oxo-1-(phenylmethyl)butyl>carbamic acid 1,1-dimethylethyl ester (151103-60-5) → (2R,4S)-2-((R)-Benzylcarbamoyl-phenylacetylamino-methyl)-5,5-dimethyl-thiazolidine-4-carboxylic acid ((1R,2S)-1-benzyl-3-carbamoyl-2-hydroxy-propyl)-amide

Guidance literature:

Multi-step reaction with 2 steps

1: HCl(g) / dioxane / 2 h / Ambient temperature

2: N,N-diisopropylethylamine (DIPEA), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) / dimethylformamide / Ambient temperature

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm00073a012