2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Base Information

Chemical Name:2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine
CAS No.:1332876-06-8
Molecular Formula:C₂₀H₁₇F₃N₄O
Molecular Weight:386.376
Hs Code.:

Synonyms:2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

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Chemical Property of 2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

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Technology Process of 2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

There total 6 articles about 2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332876-08-0
3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide

: 1332876-06-8
2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: 3-tert-butyl-isoxazole-5-carboxylic acid [3-nitro-6-(2-trifluoromethyl-phenyl)-pyridin-2-yl]-amide; With iron; acetic acid; at 100 ℃; for 2h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 133674-40-5
3-tert-butylisoxazole-5-carboxylic acid

: 1332876-06-8
2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2: tetrahydrofuran; mineral oil / 0.25 h / 20 °C

3: iron / acetic acid / 2 h / 100 °C

With oxalyl dichloride; iron; N,N-dimethyl-formamide; acetic acid; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 84487-04-7
6-bromo-3-nitro-pyridin-2-ylamine

: 1332876-06-8
2-(3-tert-butyl-isoxazol-5-yl)-5-(2-trifluoromethyl-phenyl)-1H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 1 h / 20 °C

2: tetrahydrofuran / 0.25 h / 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 18 h / 80 °C / Inert atmosphere

4: tetrahydrofuran; mineral oil / 1 h / 20 °C

5: tetrahydrofuran; mineral oil / 0.25 h / 20 °C

6: iron / acetic acid / 2 h / 100 °C

With iron; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; water; mineral oil; 3: Suzuki Coupling;