ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate

Base Information

• Chemical Name: ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate
• CAS No.: 334537-37-0
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.415
• Mol file: 334537-37-0.mol

Synonyms:ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate

Chemical Property of ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate

There total 1 articles about ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-methylalanine ethyl ester (1113-49-1) + Z-Aib-OH (15030-72-5) → ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate (334537-37-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 50 ℃; for 12h;

DOI:10.1002/1522-2675(20010131)84:1<32::AID-HLCA32>3.0.CO;2-4

Reference yield:

ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate (334537-37-0) → ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycyl-dimethylglycinate (334537-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / H₂ / 5 percent Pd-C / methanol / 5 h

2: 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide*HCl; HOBt / CH₂Cl₂ / 36 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/1522-2675(20010131)84:1<32::AID-HLCA32>3.0.CO;2-4

Reference yield:

ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate (334537-37-0) → ethyl 2-{{2-{{2-{{2-{[(benzyloxy)carbonyl]amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methylpropanoate (334537-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / H₂ / 5 percent Pd-C / methanol / 5 h

2: 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide*HCl; HOBt / CH₂Cl₂ / 36 h / 20 °C

3: H₂ / 5 percent Pd-C / methanol / 5 h

4: 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide*HCl; HOBt / CH₂Cl₂ / 36 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1002/1522-2675(20010131)84:1<32::AID-HLCA32>3.0.CO;2-4

upstream raw materials:

2-methylalanine ethyl ester

Z-Aib-OH

Downstream raw materials:

ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycyl-dimethylglycinate

ethyl 2-{{2-{{2-{{2-{[(benzyloxy)carbonyl]amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methylpropanoate