[(3S,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-2-hydroxy-3,5-dimethylhexyl]-phosphonic acid dimethyl ester

Base Information

• Chemical Name: [(3S,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-2-hydroxy-3,5-dimethylhexyl]-phosphonic acid dimethyl ester
• CAS No.: 1239584-95-2
• Molecular Formula: C₃₂H₅₅O₆PSi₂
• Molecular Weight: 622.93
• Mol file: 1239584-95-2.mol

Synonyms:[(3S,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-2-hydroxy-3,5-dimethylhexyl]-phosphonic acid dimethyl ester

Chemical Property of [(3S,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-2-hydroxy-3,5-dimethylhexyl]-phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3S,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-2-hydroxy-3,5-dimethylhexyl]-phosphonic acid dimethyl ester

There total 1 articles about [(3S,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-2-hydroxy-3,5-dimethylhexyl]-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R,4R)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2,4-dimethylpentanal (1078119-00-2) + dimethyl methane phosphonate (756-79-6) → [(3S,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-2-hydroxy-3,5-dimethylhexyl]-phosphonic acid dimethyl ester (1239584-95-2)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h; Inert atmosphere;

(2R,3R,4R)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2,4-dimethylpentanal; In tetrahydrofuran; hexanes; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; hexanes; water; Inert atmosphere;

DOI:10.1021/ol101145t

Reference yield: 97.0%

[(3S,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-2-hydroxy-3,5-dimethylhexyl]-phosphonic acid dimethyl ester (1239584-95-2) → [(3R,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-3,5-dimethyl-2-oxo-hexyl]-phosphonic acid dimethyl ester (1239584-96-3)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; Inert atmosphere;

DOI:10.1021/ol101145t

upstream raw materials:

(2R,3R,4R)-3-((tert-butyldimethylsilyl)oxy)-5-((tert-butyldiphenylsilyl)oxy)-2,4-dimethylpentanal

dimethyl methane phosphonate

Downstream raw materials:

[(3R,4R,5R)-4-(tert-butyldimethylsilanyloxy)-6-(tert-butyldiphenylsilanyloxy)-3,5-dimethyl-2-oxo-hexyl]-phosphonic acid dimethyl ester