(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate
CAS No.:1239279-22-1
Molecular Formula:C₁₆H₂₁Cl₂NO₄
Molecular Weight:362.253
Hs Code.:

Synonyms:(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate

Chemical Property:

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Technology Process of (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate

There total 6 articles about (R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 335395-63-6
(R)-(2-(3,4-dichlorophenyl)morpholin-2-yl)methanol

: 1239279-22-1
(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 16h;
DOI:10.1021/ol101555g

Reference yield:

: 1239279-19-6
(R)-ethyl 3-amino-2-(3,4-dichlorophenyl)-2-hydroxypropanoate

: 1239279-22-1
(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 4 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

3.1: borane-THF / tetrahydrofuran / 3 h / Reflux

3.2: 1 h / Reflux

4.1: triethylamine / methanol / 16 h / 20 °C

With borane-THF; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo102471r

Reference yield:

: 1239279-18-5
(R)-ethyl 2-(3,4-dichlorophenyl)-2-hydroxy-3-nitropropanoate

: 1239279-22-1
(R)-tert-butyl 2-(3,4-dichlorophenyl)-2-(hydroxymethyl)morpholine-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; zinc

2.1: triethylamine / dichloromethane / 4 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.1: borane-THF / tetrahydrofuran / 3 h / Reflux

4.2: 1 h / Reflux

5.1: triethylamine / methanol / 16 h / 20 °C

With borane-THF; sodium hydride; acetic acid; triethylamine; zinc; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo102471r