2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide

Base Information

Chemical Name:2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide
CAS No.:226888-40-0
Molecular Formula:C₂₅H₂₄FN₃O₆
Molecular Weight:481.48
Hs Code.:

Synonyms:2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide

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Technology Process of 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide

There total 9 articles about 2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 226888-23-9
2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-isopropoxy-4-methoxybenzyl)-3-phenylpropionamide

: 226888-40-0
2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide

Guidance literature:: With boron trichloride; In dichloromethane; at 0 ℃; for 1.5h;
DOI:10.1016/S0040-4020(99)00171-4

Reference yield:

: 621-59-0
isovanillin

: 226888-40-0
2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / K₂CO₃ / dimethylformamide / 3 h / 80 °C

2: 96 percent / NaN₃, aluminium trichloride / tetrahydrofuran / 24 h / Heating

3: 1.) BH₃, 2.) conc. HCl / 1) THF, 0 deg C, 10 min, rt, 20 min, 75 deg C, 3 h

4: 1.) NEt₃, 2.) EDC, HOBT / 1) DMF, 10 min; 2) DMF, rt, 6 h

5: 1.) CF₃COOH, 2.) NEt₃, HOBT, EDC / 1) CH₂Cl₂, rt, 30 min; 2) CH₂Cl₂, rt, 10 h

6: 80 percent / BCl₃ / CH₂Cl₂ / 1.5 h / 0 °C

With hydrogenchloride; aluminium trichloride; sodium azide; borane; boron trichloride; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(99)00171-4

Reference yield:

: 34123-66-5
O-isopropylisovanillin

: 226888-40-0
2-<(2R)-2-(4-fluoro-3-nitrophenyl)-acetylamino>-N-(3-hydroxy-4-methoxybenzyl)-3-phenylpropionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / NaN₃, aluminium trichloride / tetrahydrofuran / 24 h / Heating

2: 1.) BH₃, 2.) conc. HCl / 1) THF, 0 deg C, 10 min, rt, 20 min, 75 deg C, 3 h

3: 1.) NEt₃, 2.) EDC, HOBT / 1) DMF, 10 min; 2) DMF, rt, 6 h

4: 1.) CF₃COOH, 2.) NEt₃, HOBT, EDC / 1) CH₂Cl₂, rt, 30 min; 2) CH₂Cl₂, rt, 10 h

5: 80 percent / BCl₃ / CH₂Cl₂ / 1.5 h / 0 °C

With hydrogenchloride; aluminium trichloride; sodium azide; borane; boron trichloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0040-4020(99)00171-4