2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide

Base Information

Chemical Name:2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide
CAS No.:1190424-86-2
Molecular Formula:C₃₃H₂₉N₅O₂
Molecular Weight:527.626
Hs Code.:

Synonyms:2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide

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Chemical Property of 2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide

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Technology Process of 2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide

There total 4 articles about 2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187617-39-5
4-(quinolin-3-yl)-9H-carbazole

: 1190424-87-3
6-chloro-4-(4-trans-hydroxycyclohexyl)aminonicotinamide

: 1190424-86-2
2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide

Guidance literature:: With caesium carbonate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; at 50 - 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 52602-39-8
9H-carbazol-4-ol

: 1190424-86-2
2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.5 h / 115 °C / microwave irradiation

3: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 50 - 90 °C / Inert atmosphere

With sodium carbonate; caesium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 1187617-32-8
9H-carbazol-4-yl-trifluoromethanesulfonate

: 1190424-86-2
2-[4-(quinolin-3-yl)-9H-carbazol-9-yl]-4-(4-trans-hydroxycyclohexylamino)pyridine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.5 h / 115 °C / microwave irradiation

2: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 3 h / 50 - 90 °C / Inert atmosphere

With sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; toluene;