Technology Process of C16H16F5NO4
There total 4 articles about C16H16F5NO4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
DOI:10.1021/ol1024663
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h
1.2: 0 - 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C
3.2: -78 - 20 °C
4.1: pyridine / N,N-dimethyl-formamide / 0 - 20 °C
With
pyridine; lithium aluminium tetrahydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
3.1: Horner-Wadsworth-Emmons olefination / 3.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ol1024663
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C
1.2: -78 - 20 °C
2.1: pyridine / N,N-dimethyl-formamide / 0 - 20 °C
With
pyridine; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ol1024663
