thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester

Base Information

Chemical Name:thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester
CAS No.:922167-83-7
Molecular Formula:C₄₁H₄₆O₈S
Molecular Weight:698.877
Hs Code.:

thiocarbonic acid <i>O</i>-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester <i>O</i>-phenyl ester

Synonyms:thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester

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Chemical Property of thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester

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Technology Process of thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester

There total 12 articles about thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 922167-80-4
thiocarbonic acid O-(3-hydroxy-2-{4-hydroxy-2-(4-methoxy-phenyl)-6-[2-(4-methoxy-phenyl)-ethyl]-tetrahydro-pyran-3-yl}-propyl) ester O-phenyl ester

: 20401-88-1
3-(4-methoxyphenyl)propional

: 922167-83-7
thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester

Guidance literature:: With 3-(chlorocarbonothioyl)-1-methyl-1H-imidazol-3-ium chloride; In dichloromethane; for 1.5h; Heating;
DOI:10.1021/ol0627956

Reference yield:

: 20401-88-1
3-(4-methoxyphenyl)propional

: 922167-83-7
thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: (R)-BINOL; silver(I) oxide; TiCl₄ / Ti(Oi-Pr)4 / CH₂Cl₂ / cooling

2: Hoveyda-Grubbs second generation catalyst / CH₂Cl₂ / 24 h / 20 °C

3: triethylsilyl triflate; acetic acid / 1 h / 20 °C

4: potassium carbonate / methanol / 3 h / 20 °C

5: pyridine / CH₂Cl₂ / 0 - 20 °C

6: N-methyl-N'-chlorosulfinylimidazolium chloride / CH₂Cl₂ / 1.5 h / Heating

With pyridine; triethylsilyl trifluoromethyl sulfonate; (R)-1,1'-Bi-2-naphthol; titanium tetrachloride; potassium carbonate; acetic acid; silver(l) oxide; titanium(IV) isopropylate; Hoveyda-Grubbs catalyst second generation; In methanol; dichloromethane;
DOI:10.1016/j.tet.2007.02.028

Reference yield:

: 922167-72-4
(-)-(3S)-1-(4-methoxyphenyl)hex-5-en-3-ol

: 922167-83-7
thiocarbonic acid O-{1-(4-methoxy-phenyl)-3,6-bis-[2-(4-methoxy-phenyl)-ethyl]-hexahydro-2,5,7-trioxa-benzocyclohepten-9-ylmethyl} ester O-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Hoveyda-Grubbs second generation catalyst / CH₂Cl₂ / 24 h / 20 °C

2: triethylsilyl triflate; acetic acid / 1 h / 20 °C

3: potassium carbonate / methanol / 3 h / 20 °C

4: pyridine / CH₂Cl₂ / 0 - 20 °C

5: N-methyl-N'-chlorosulfinylimidazolium chloride / CH₂Cl₂ / 1.5 h / Heating

With pyridine; triethylsilyl trifluoromethyl sulfonate; potassium carbonate; acetic acid; Hoveyda-Grubbs catalyst second generation; In methanol; dichloromethane;
DOI:10.1016/j.tet.2007.02.028