2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester

Base Information

• Chemical Name: 2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester
• CAS No.: 22888-57-9
• Molecular Formula: C₄₅H₃₉N₃O₂
• Molecular Weight: 653.824
• Mol file: 22888-57-9.mol

Synonyms:2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester

Chemical Property of 2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester

There total 1 articles about 2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trityl chloride (76-83-5) + l-histidine methyl ester dihydrochloride (4467-54-3,5619-10-3,7389-87-9,18684-16-7,22888-60-4,32381-17-2,92742-29-5,100009-20-9) → 2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester (22888-57-9)

Guidance literature:

With triethylamine; In acetonitrile; Ambient temperature;

DOI:10.1021/jm980408v

Reference yield: 93.0%

2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester (22888-57-9) → 2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanol ditrityl-L-histidinol (223910-41-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1016/j.tet.2011.11.066

Reference yield: 93.0%

2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanoic acid methyl ester ditrityl-L-histidine methyl ester (22888-57-9) + trifluoroacetic acid (76-05-1) → (L)-H-His(Trt)-OMe*TFA

Guidance literature:

In dichloromethane; at 0 ℃; for 0.0166667h;

upstream raw materials:

trityl chloride

l-histidine methyl ester dihydrochloride

Downstream raw materials:

2-(S)-(triphenylmethylamino)-3-<1-(triphenylmethyl)imidazol-4(5)-yl>propanol ditrityl-L-histidinol

N^im-triphenylmethyl-L-histidine methyl ester

Fmoc-(His(Trt))2-OMe

2-amino-3-(3-benzyl-3h-imidazol-4-yl)-propionic acid methyl ester