3-(2-Hydroxy-1-phenyl-ethyl)-2-mercapto-3H-thieno[3,2-d]pyrimidin-4-one

Base Information

• Chemical Name: 3-(2-Hydroxy-1-phenyl-ethyl)-2-mercapto-3H-thieno[3,2-d]pyrimidin-4-one
• CAS No.: 126637-01-2
• Molecular Formula: C₁₄H₁₂N₂O₂S₂
• Molecular Weight: 304.393
• Mol file: 126637-01-2.mol

Synonyms:3-(2-Hydroxy-1-phenyl-ethyl)-2-mercapto-3H-thieno[3,2-d]pyrimidin-4-one

Chemical Property of 3-(2-Hydroxy-1-phenyl-ethyl)-2-mercapto-3H-thieno[3,2-d]pyrimidin-4-one

Chemical Property:

Purity/Quality:

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Technology Process of 3-(2-Hydroxy-1-phenyl-ethyl)-2-mercapto-3H-thieno[3,2-d]pyrimidin-4-one

There total 1 articles about 3-(2-Hydroxy-1-phenyl-ethyl)-2-mercapto-3H-thieno[3,2-d]pyrimidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-isothiocyanato-2-thiophenecarboxylic acid methyl ester (81321-10-0) + Phenylglycinol (20989-17-7,56613-80-0,71006-16-1,7568-92-5,188586-38-1) → 3-(2-Hydroxy-1-phenyl-ethyl)-2-mercapto-3H-thieno[3,2-d]pyrimidin-4-one (126637-01-2)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction; 1.) THF, RT; 2.5 h,;

DOI:10.1248/cpb.37.2122

Reference yield: 80.0%

3-(2-Hydroxy-1-phenyl-ethyl)-2-mercapto-3H-thieno[3,2-d]pyrimidin-4-one (126637-01-2) → 7-Phenyl-6,7-dihydro-thiazolo[3,2-a]thieno[3,2-d]pyrimidin-9-one; hydrate

Guidance literature:

With methanesulfonic acid; at 120 - 130 ℃; for 0.5h;

DOI:10.1248/cpb.37.2122

upstream raw materials:

3-isothiocyanato-2-thiophenecarboxylic acid methyl ester

Phenylglycinol