6-Methylene-3,3-diphenyl-1,4-cyclohexadiene

Base Information

• Chemical Name: 6-Methylene-3,3-diphenyl-1,4-cyclohexadiene
• CAS No.: 18636-59-4
• Molecular Formula: C₁₉H₁₆
• Molecular Weight: 244.336
• Mol file: 18636-59-4.mol

Synonyms:1-Methylen-4,4-diphenyl-cyclohexa-2,5-dien

Chemical Property of 6-Methylene-3,3-diphenyl-1,4-cyclohexadiene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Methylene-3,3-diphenyl-1,4-cyclohexadiene

There total 4 articles about 6-Methylene-3,3-diphenyl-1,4-cyclohexadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-4,4-diphenylcyclohex-2-en-1-one (33733-00-5) → 1-Methylen-4,4-diphenyl-cyclohexa-2,5-dien (18636-59-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Li₂CO₃, LiBr / dimethylformamide

2: (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2050486/

With lithium carbonate; lithium bromide; In N,N-dimethyl-formamide;

DOI:10.1021/ja00744a018

Reference yield:

4,4-diphenyl-2-cyclohexen-1-one (4528-64-7) → 1-Methylen-4,4-diphenyl-cyclohexa-2,5-dien (18636-59-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) TsOH, (heating), (ii) Br₂, CCl₄

2: Li₂CO₃, LiBr / dimethylformamide

3: (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2050486/

With lithium carbonate; lithium bromide; In N,N-dimethyl-formamide;

DOI:10.1021/ja00744a018

Reference yield:

4,4-diphenyl-2,5-cyclohexadien-1-one (13304-12-6) + methyl triphenylphosphonium bromide (27200-84-6) → 1-Methylen-4,4-diphenyl-cyclohexa-2,5-dien (18636-59-4)

Guidance literature:

Multistep reaction; (i) nBuLi, Et₂O, hexane, (ii) /BRN= 2050486/;

DOI:10.1021/ja00744a018

upstream raw materials:

4,4-diphenyl-2,5-cyclohexadien-1-one

methyl triphenylphosphonium bromide

6-bromo-4,4-diphenylcyclohex-2-en-1-one

4,4-diphenyl-2-cyclohexen-1-one

Downstream raw materials:

3,3,12,12-Tetraphenyl-dispiro[5.2.5.2]hexadeca-1,4,7,10,13-pentaene-7,8-dicarbonitrile