6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1336965-02-6
Molecular Formula:C₂₉H₃₂F₃N₃O₄
Molecular Weight:543.586
Hs Code.:

Synonyms:6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Chemical Property of 6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

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Technology Process of 6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 5 articles about 6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1336965-00-4
methyl 6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylate

: 1336965-02-6
6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: With water; potassium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 168h;

Reference yield:

: 5-ethoxy-indol-2,3-dione

: 1336965-02-6
6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 0.17 h

1.2: 18 h / Reflux

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane; tetrahydrofuran / 1 h / 0 °C

2.2: 20 °C

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 24 h / 100 °C

4.1: acetonitrile / 18 h / 20 °C

5.1: potassium hydroxide; water / tetrahydrofuran; methanol / 168 h / 70 °C

With N-Bromosuccinimide; oxalyl dichloride; water; potassium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1336903-94-6
6-(ethyloxy)-3-methyl-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 1336965-02-6
6-(ethyloxy)-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane; tetrahydrofuran / 1 h / 0 °C

1.2: 20 °C

2.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 24 h / 100 °C

3.1: acetonitrile / 18 h / 20 °C

4.1: potassium hydroxide; water / tetrahydrofuran; methanol / 168 h / 70 °C

With N-Bromosuccinimide; oxalyl dichloride; water; potassium hydroxide; dibenzoyl peroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; acetonitrile;