Technology Process of 1,3,4-tri-O-benzyl-2-O-<2-O-(benzyloxymethyl)-β-D-ribofuranosyl>-5-O-pivaloyl-D-ribitol
There total 11 articles about 1,3,4-tri-O-benzyl-2-O-<2-O-(benzyloxymethyl)-β-D-ribofuranosyl>-5-O-pivaloyl-D-ribitol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
1,4-dioxane;
at 20 ℃;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 85 percent / trimethylsilyl trifluoromethylmethanesulfonate / 1,2-dichloro-ethane / Ambient temperature; a) molecular sieves 4 Angstroem, 1 h, b) 1 h
2: 85 percent / sodium methoxide / dioxane; methanol / 2 h / 20 °C
3: 82 percent / pyridine / 1 h / 20 °C
4: 87 percent / diisopropylethylamine / acetonitrile / 50 °C
5: tetra-n-butylammonium fluoride / dioxane / 0.5 h / 20 °C
With
pyridine; trimethylsilyl trifluoromethylmethanesulfonate; tetrabutyl ammonium fluoride; sodium methylate; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; 1,2-dichloro-ethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / sodium hydride / dimethylformamide / 12 h / 20 °C
2: 1M hydrogen chloride / acetic acid; H2O / 2 h / 100 °C
3: 87 percent / sodium borohydride / ethanol / 1 h / 50 °C
4: 95 percent / pyridine / CH2Cl2 / Ambient temperature
5: 85 percent / trimethylsilyl trifluoromethylmethanesulfonate / 1,2-dichloro-ethane / Ambient temperature; a) molecular sieves 4 Angstroem, 1 h, b) 1 h
6: 85 percent / sodium methoxide / dioxane; methanol / 2 h / 20 °C
7: 82 percent / pyridine / 1 h / 20 °C
8: 87 percent / diisopropylethylamine / acetonitrile / 50 °C
9: tetra-n-butylammonium fluoride / dioxane / 0.5 h / 20 °C
With
pyridine; hydrogenchloride; sodium tetrahydroborate; trimethylsilyl trifluoromethylmethanesulfonate; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
