cyclohexylpropionyl-glycine benzyl ester

Base Information

• Chemical Name: cyclohexylpropionyl-glycine benzyl ester
• CAS No.: 243139-90-4
• Molecular Formula: C₁₈H₂₅NO₃
• Molecular Weight: 303.401
• Mol file: 243139-90-4.mol

Synonyms:cyclohexylpropionyl-glycine benzyl ester

Chemical Property of cyclohexylpropionyl-glycine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of cyclohexylpropionyl-glycine benzyl ester

There total 1 articles about cyclohexylpropionyl-glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclohexanepropionic acid (701-97-3) + glycine benzyl ester p-toluenesulfonic acid salt (1738-76-7) → cyclohexylpropionyl-glycine benzyl ester (243139-90-4)

Guidance literature:

cyclohexanepropionic acid; With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃;

glycine benzyl ester p-toluenesulfonic acid salt; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1007/PL00010276

Reference yield: 92.0%

cyclohexylpropionyl-glycine benzyl ester (243139-90-4) → cyclohexylpropionyl-glycine (243139-91-5)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1007/PL00010276

Reference yield:

cyclohexylpropionyl-glycine benzyl ester (243139-90-4) → 5'-O-(cyclohexylpropionyl-glycyl)-2',3'-O-isopropylideneuridine

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / ammonium formate / 10 percent Pd/C / methanol / 0.17 h / 20 °C

2.1: DCC / dimethylformamide / 0 °C

2.2: 30 percent / 4-dimethylaminopyridine / dimethylformamide / 20 °C

With ammonium formate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1.1: Hydrogenolysis / 2.1: Addition / 2.2: Esterification;

DOI:10.1007/PL00010276

upstream raw materials:

cyclohexanepropionic acid

glycine benzyl ester p-toluenesulfonic acid salt

Downstream raw materials:

cyclohexylpropionyl-glycine