(2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid

Base Information

• Chemical Name: (2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid
• CAS No.: 376634-65-0
• Molecular Formula: C₂₇H₂₄BrNO₃
• Molecular Weight: 490.396

Synonyms:(2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid

Chemical Property of (2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid

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Technology Process of (2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid

There total 4 articles about (2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

ethyl (2R)-2-{4-[1-(4-bromophenyl)-5-methyl-3-propyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoate (376634-68-3) → (2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid (376634-65-0) + (2R)-2-{4-[1-(4-Bromophenyl)-5-methyl-3-propyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid (376634-69-4)

Guidance literature:

Reference yield: 89.5%

aqueous potassium hydroxide + ethyl (2R)-2-{4-[1-(4-bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoate (376634-64-9) → (2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid (376634-65-0)

Guidance literature:

In THF (6 ml)-methanol;

Reference yield: 88.8%

ethyl (2R)-2-{4-[1-(4-bromophenyl)-5-methyl-3-phenyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoate (376634-70-7) → (2R)-2-{4-[1-(4-Bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid (376634-65-0) + (2R)-2-{4-[1-(4-Bromophenyl)-5-methyl-3-phenyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoic acid (376634-71-8)

Guidance literature:

upstream raw materials:

ethyl (2R)-2-{4-[1-(4-bromophenyl)-4,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoate

ethyl (2R)-2-{4-[1-(4-bromophenyl)-3,5-dimethyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoate

ethyl (2R)-2-{4-[1-(4-bromophenyl)-5-methyl-3-propyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoate

ethyl (2R)-2-{4-[1-(4-bromophenyl)-5-methyl-3-phenyl-1H-pyrrol-2-yl]phenoxy}-3-phenylpropanoate

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