4-(2-Bromo-5-hydroxybenzyl)morpholine

Base Information

• Chemical Name: 4-(2-Bromo-5-hydroxybenzyl)morpholine
• CAS No.: 937636-52-7
• Molecular Formula: C₁₁H₁₄BrNO₂
• Molecular Weight: 272.142
• Mol file: 937636-52-7.mol

Synonyms:4-bromo-3-(morpholinomethyl)phenol

Chemical Property of 4-(2-Bromo-5-hydroxybenzyl)morpholine

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Bromo-5-hydroxybenzyl)morpholine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(2-Bromo-5-hydroxybenzyl)morpholine

There total 1 articles about 4-(2-Bromo-5-hydroxybenzyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

morpholine (110-91-8,99108-56-2) + 2-bromo-5-hydroxybenzaldehyde (2973-80-0) → 4-bromo-3-(morpholinomethyl)phenol (937636-52-7)

Guidance literature:

morpholine; 2-bromo-5-hydroxybenzaldehyde; In dichloromethane; for 0.333333h; Inert atmosphere;

With sodium tris(acetoxy)borohydride; In dichloromethane; for 2h; Inert atmosphere;

DOI:10.1021/jm5001216

Reference yield: 97.0%

Triisopropyl borate (5419-55-6) + 4-bromo-3-(morpholinomethyl)phenol (937636-52-7) → 4-hydroxy-2-(morpholinomethyl)phenylboronic acid (1038827-78-9)

Guidance literature:

4-bromo-3-(morpholinomethyl)phenol; With tert.-butyl lithium; In tetrahydrofuran; at -78 - 0 ℃; for 0.416667h;

Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

4-bromo-3-(morpholinomethyl)phenol (937636-52-7) → 4-hydroxy-2-(morpholinomethyl)phenylboronic acid (1038827-78-9)

Guidance literature:

4-bromo-3-(morpholinomethyl)phenol; With tert.-butyl lithium; In tetrahydrofuran; at -78 - 0 ℃; for 0.416667h; Inert atmosphere;

With Triisopropyl borate; In tetrahydrofuran; at -78 - 25 ℃; for 1h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran; water; at 18 - 25 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm5001216

upstream raw materials:

morpholine

2-bromo-5-hydroxybenzaldehyde

Downstream raw materials:

4-hydroxy-2-(morpholinomethyl)phenylboronic acid

Refernces

• 1、 -. "PHENOXYPYRIDINYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PDE4 MEDIATED DISEASE STATES". Page/Page column 45-46. . Retrieved 2009/12/27.