BOC-LYS-AMC

Base Information

• Chemical Name: BOC-LYS-AMC
• CAS No.: 116883-12-6
• Molecular Formula: C₂₁H₂₉N₃O₅
• Molecular Weight: 403.478
• Mol file: 116883-12-6.mol

Synonyms:Carbamicacid, [(1S)-5-amino-1-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)amino]carbonyl]pentyl]-,1,1-dimethylethyl ester (9CI); Carbamic acid,[5-amino-1-[[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)amino]carbonyl]pentyl]-,1,1-dimethylethyl ester, (S)-

Chemical Property of BOC-LYS-AMC

Chemical Property:

• PSA: 123.66000
• LogP: 4.22640
• Storage Temp.: -15°C
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

Boc-L-Lys-AmcAceticAcidSalt(~90%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Boc-L-Lys-Amc (cas# 116883-12-6) is a compound useful in organic synthesis.

Technology Process of BOC-LYS-AMC

There total 5 articles about BOC-LYS-AMC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

Boc-Lys(Fmoc)-AMC → N-(4-methyl-7-coumarinyl)-N-α-(tert-butyloxycarbonyl)-lysinamide (116883-12-6)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; for 0.25h;

Reference yield:

N-(4-methyl-7-coumarinyl)-N-α-(tert-butyloxycarbonyl)-N-ω-acetyl-lysinamide (233691-67-3) → N-(4-methyl-7-coumarinyl)-N-α-(tert-butyloxycarbonyl)-lysinamide (116883-12-6)

Guidance literature:

With rat liver histone deacetylase; In ethanol; for 1h; Further Variations:; Reagents; Enzyme kinetics; Enzymatic reaction;

Reference yield:

7-amino-4-methylcoumarin. (26093-31-2) → N-(4-methyl-7-coumarinyl)-N-α-(tert-butyloxycarbonyl)-lysinamide (116883-12-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / POCl₃ / pyridine / 0.5 h / -15 °C

2: 38 percent / piperidine / dimethylformamide / 0.25 h

With piperidine; trichlorophosphate; In pyridine; N,N-dimethyl-formamide;

upstream raw materials:

N-(4-methyl-7-coumarinyl)-N-α-(tert-butyloxycarbonyl)-N-ω-acetyl-lysinamide

7-amino-4-methylcoumarin.

Boc-Lys(Fmoc)-OH

Boc-Lys(trifluoroacetyl)-AMC

Downstream raw materials:

Boc-Lys-OH