3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione

Base Information

• Chemical Name: 3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione
• CAS No.: 78431-29-5
• Molecular Formula: C₁₄H₁₃BrN₄O₂
• Molecular Weight: 349.187

Synonyms:3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione

Chemical Property of 3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione

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Technology Process of 3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione

There total 6 articles about 3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

3-(4-bromo-phenyl)-1,6-dimethyl-1H-pyrimido[4,5-c]pyridazine-5,7-dione (68871-19-2) → 3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione (78431-29-5)

Guidance literature:

With sodium dithionite; In ammonium hydroxide; at 90 ℃; for 1h;

DOI:10.1248/cpb.29.379

Reference yield: 44.0%

3-(4-bromo-phenyl)-1,6-dimethyl-1H-pyrimido[4,5-c]pyridazine-5,7-dione (68871-19-2) → 3-(4-Bromo-phenyl)-1,6-dimethyl-1H,8H-pyrimido[4,5-c]pyridazine-4,5,7-trione (81976-08-1) + 3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione (78431-29-5)

Guidance literature:

With potassium hydroxide; for 6h; Heating;

DOI:10.1248/cpb.30.172

Reference yield: 16.0%

para-bromophenacyl bromide (99-73-0,132309-76-3) + 3-methyl-6-(1-methylhydrazinyl)pyrimidine-2,4(1H,3H)-dione (42747-84-2) → 3-(4-bromo-phenyl)-1,7-dimethyl-1,4-dihydro-pyrimido[6,1-c][1,2,4]triazine-6,8-dione (68871-24-9) + 3-(4-Bromo-phenyl)-1,6-dimethyl-4,8-dihydro-1H-pyrimido[4,5-c]pyridazine-5,7-dione (78431-29-5)

Guidance literature:

In ethanol; for 1.5h; Heating;

DOI:10.1248/cpb.29.379

upstream raw materials:

3-(4-bromo-phenyl)-1,6-dimethyl-1H-pyrimido[4,5-c]pyridazine-5,7-dione

para-bromophenacyl bromide

3-methyl-6-(1-methylhydrazinyl)pyrimidine-2,4(1H,3H)-dione

3-(4-Bromo-phenyl)-1-methyl-1H-pyrimido[4,5-c]pyridazine-5,7-dione

Downstream raw materials:

3-(4-bromo-phenyl)-1,6-dimethyl-1H-pyrimido[4,5-c]pyridazine-5,7-dione

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