3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Chemical Name:3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester
CAS No.:895632-70-9
Molecular Formula:C₄₄H₄₉NO₁₂
Molecular Weight:783.873
Hs Code.:

3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1<i>H</i>-pyrrole-2,5-dicarboxylic acid dimethyl ester

Synonyms:3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Chemical Property of 3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

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Technology Process of 3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

There total 5 articles about 3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4-benzyloxy-5-methoxy-2-(methoxymethoxy)phenylboronic acid

: 895632-68-5
1-[2-(3,4-dimethoxy-phenyl)-ethyl]-3-(3-isopropoxy-4-methoxy-phenyl)-4-trifluoromethanesulfonyloxy-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

: 895632-70-9
3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; for 20h; Heating;
DOI:10.1016/j.tetlet.2006.03.121

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 895632-70-9
3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 91 percent / NaHCO₃ / acetonitrile / 2.5 h / Heating

2: 85 percent / NaH / tetrahydrofuran / 4.5 h / Heating

3: 92 percent / pyridine / 2 h / 0 °C

4: 80 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 5 h / Heating

5: 90 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 20 h / Heating

With sodium hydride; sodium hydrogencarbonate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; acetonitrile; 2: Hinsberg-type pyrrole synthesis / 4: Suzuki-Miyaura coupling / 5: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2006.03.121

Reference yield:

: 570402-52-7
dimethyl 3,4-dihydroxy-1-[2-(3,4-dimethoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate

: 895632-70-9
3-(4-benzyloxy-5-methoxy-2-methoxymethoxy-phenyl)-1-[2-(3,4-dimethoxy-phenyl)-ethyl]-4-(3-isopropoxy-4-methoxy-phenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / pyridine / 2 h / 0 °C

2: 80 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 5 h / Heating

3: 90 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran / 20 h / Heating

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; 2: Suzuki-Miyaura coupling / 3: Suzuki-Miyaura coupling;
DOI:10.1016/j.tetlet.2006.03.121