(S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine

Base Information

Chemical Name:(S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine
CAS No.:1404086-97-0
Molecular Formula:C₂₂H₂₀N₈
Molecular Weight:396.454
Hs Code.:

Synonyms:(S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine

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Chemical Property of (S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine

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Technology Process of (S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine

There total 6 articles about (S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 1404086-08-3
(S)-1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethanamine

: 767-69-1
6-bromopurine

: 1404086-97-0
(S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tert-butyl alcohol; at 80 - 120 ℃; Inert atmosphere;

Reference yield:

: 855784-39-3
tert-butyl N-(2-chloro-4-iodo-3-pyridyl)carbamate

: 1404086-97-0
(S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1.33 h / 130 °C / Inert atmosphere; Microwave irradiation

2.1: 1.25 h / 180 °C / Microwave irradiation

3.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 0.5 h / 0 - 5 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: 48 h / 130 °C

5.1: hydrogenchloride; water / methanol / 4.5 h / 80 °C

6.1: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 80 - 120 °C / Inert atmosphere

With hydrogenchloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1404086-09-4
(S)-tert-butyl 1-((3-amino-4-cyclopropylpyridin-2-yl)(phenyl)amino)-1-oxopropan-2-ylcarbamate

: 1404086-97-0
(S)-N-(1-(7-cyclopropyl-3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 48 h / 130 °C

2: hydrogenchloride; water / methanol / 4.5 h / 80 °C

3: N-ethyl-N,N-diisopropylamine / tert-butyl alcohol / 80 - 120 °C / Inert atmosphere

With hydrogenchloride; water; N-ethyl-N,N-diisopropylamine; In methanol; tert-butyl alcohol;