Acetic acid (Z)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester

Base Information

• Chemical Name: Acetic acid (Z)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester
• CAS No.: 125576-94-5
• Molecular Formula: C₁₇H₂₄O₆
• Molecular Weight: 324.374
• Mol file: 125576-94-5.mol

Synonyms:Acetic acid (Z)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester

Chemical Property of Acetic acid (Z)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (Z)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester

There total 18 articles about Acetic acid (Z)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

acetic anhydride (108-24-7) + 1-(4-Methoxy-benzyloxy)-2-methoxymethoxy-pentan-3-one (125638-86-0) → dl-3-acetoxy-1-p-methoxybenzyloxy-2-methoxymethoxy-3-pentene (125061-39-4,125061-47-4,125134-52-3) + Acetic acid (E)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester (125576-94-5) + Acetic acid (Z)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester (125576-94-5)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

Reference yield: 47.0%

acetic anhydride (108-24-7) + 1-(4-Methoxy-benzyloxy)-2-methoxymethoxy-pentan-3-one (125638-86-0) → dl-3-acetoxy-1-p-methoxybenzyloxy-2-methoxymethoxy-3-pentene (125061-39-4,125061-47-4,125134-52-3) + Acetic acid (E)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester (125576-94-5) + Acetic acid (Z)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester (125576-94-5)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

Reference yield:

Acetic acid 1-acetoxymethyl-2-(4-methoxy-benzyloxy)-ethyl ester (13754-08-0) → Acetic acid (E)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propenyl ester (125576-94-5)

Guidance literature:

Multi-step reaction with 6 steps

1: i-Pr₂NEt / CH₂Cl₂

2: NaOH / methanol

3: Swern oxidn.

4: tetrahydrofuran

5: Swern oxidn.

6: 47 percent / LDA / tetrahydrofuran / -78 °C

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

acetic anhydride

1-(4-Methoxy-benzyloxy)-2-methoxymethoxy-pentan-3-one

Acetic acid 1-acetoxymethyl-2-(4-methoxy-benzyloxy)-ethyl ester

2-(4-Methoxy-benzyloxy)-oxirane

Downstream raw materials:

(R)-1-(4-Methoxy-benzyloxy)-2-methoxymethoxy-pentan-3-one

(S)-1-(4-Methoxy-benzyloxy)-2-methoxymethoxy-pentan-3-one

(R)-1-(4-Methoxy-benzyloxy)-2-methoxymethoxy-pentan-3-ol

(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (R)-1-ethyl-3-(4-methoxy-benzyloxy)-2-methoxymethoxy-propyl ester