(S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate

Base Information

• Chemical Name: (S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate
• CAS No.: 1338482-07-7
• Molecular Formula: C₂₀H₂₂FN₃O₂
• Molecular Weight: 355.412
• Mol file: 1338482-07-7.mol

Synonyms:(S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate

Chemical Property of (S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate

There total 7 articles about (S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

L-N-Boc-Ala (15761-38-3) + 5-fluoro-N1-phenylbenzene-1,2-diamine (325-61-1) → (S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate (1338482-07-7)

Guidance literature:

L-N-Boc-Ala; 5-fluoro-N₁-phenylbenzene-1,2-diamine; With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 21h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

(S)-tert-butyl 1-(6-fluoro-1H-benzo[d]imidazol-2-yl )-ethylcarbamate (1338482-06-6) + phenylboronic acid (98-80-6) → (S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate (1338482-07-7) + (S)-tert-butyl 1-(5-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate (1338482-08-8)

Guidance literature:

With pyridine; copper diacetate; In dichloromethane; at 20 ℃; for 120h;

Reference yield:

L-N-Boc-Ala (15761-38-3) → (S)-tert-butyl 1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate (1338482-07-7) + (S)-tert-butyl 1-(5-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethylcarbamate (1338482-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.33 h / 20 °C

2: pyridine / copper diacetate / dichloromethane / 120 h / 20 °C

With pyridine; copper diacetate; In dichloromethane;

upstream raw materials:

(S)-tert-butyl 1-(6-fluoro-1H-benzo[d]imidazol-2-yl )-ethylcarbamate

phenylboronic acid

L-N-Boc-Ala

4-fluoro-1,2-phenylenediamine

Downstream raw materials:

(S)-1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethanamine

(S)-N-(1-(6-fluoro-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine