3-amino-6-(2,6-difluorophenyl)picolinic acid

Base Information

Chemical Name:3-amino-6-(2,6-difluorophenyl)picolinic acid
CAS No.:1052714-89-2
Molecular Formula:C₁₂H₈F₂N₂O₂
Molecular Weight:250.205
Hs Code.:

Synonyms:3-amino-6-(2,6-difluorophenyl)picolinic acid

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Chemical Property of 3-amino-6-(2,6-difluorophenyl)picolinic acid

Chemical Property:

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Technology Process of 3-amino-6-(2,6-difluorophenyl)picolinic acid

There total 4 articles about 3-amino-6-(2,6-difluorophenyl)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1052714-87-0
methyl 3-amino-6-(2,6-difluorophenyl)picolinate

3-amino-6-(2,6-difluorophenyl)picolinic acid: 1052714-89-2
3-amino-6-(2,6-difluorophenyl)picolinic acid

Guidance literature:: methyl 3-amino-6-(2,6-difluorophenyl)picolinate; With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 866775-09-9
methyl 3-amino-6-bromopyridine-2-carboxylate

: 162101-25-9
2,6-difluorophenylboronic acid

3-amino-6-(2,6-difluorophenyl)picolinic acid: 1052714-89-2
3-amino-6-(2,6-difluorophenyl)picolinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 120 °C / Microwave irradiation

2: lithium hydroxide / tetrahydrofuran / 4 h / 60 °C

With sodium carbonate; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,2-dimethoxyethane; 1: Suzuki Coupling;

Reference yield:

: 866775-09-9
methyl 3-amino-6-bromopyridine-2-carboxylate

3-amino-6-(2,6-difluorophenyl)picolinic acid: 1052714-89-2
3-amino-6-(2,6-difluorophenyl)picolinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 0.25 h / 120 °C / Microwave irradiation

2: lithium hydroxide / tetrahydrofuran / 4 h / 60 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1021/ml400307j