(S)-N-(trans-4-phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide

Base Information

• Chemical Name: (S)-N-(trans-4-phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide
• CAS No.: 917769-72-3
• Molecular Formula: C₂₅H₂₈F₃NO₂
• Molecular Weight: 431.498
• Mol file: 917769-72-3.mol

Synonyms:(S)-N-(trans-4-phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide

Chemical Property of (S)-N-(trans-4-phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-N-(trans-4-phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide

There total 1 articles about (S)-N-(trans-4-phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

N-cyclopropyl-4-phenylcyclohexylamine + (S)-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl) benzoic acid (917771-46-1) → (S)-N-(trans-4-phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide (917769-72-3) + (S)-N-(cis-4-phenyl)cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)-N-cyclopropylbenzamide (917769-73-4)

Guidance literature:

With sodium hydrogencarbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 12h;

DOI:10.1021/jm800310g

upstream raw materials:

(S)-4-(1,1,1-trifluoro-2-hydroxypropan-2-yl) benzoic acid