[4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid

Base Information

• Chemical Name: [4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid
• CAS No.: 480994-15-8
• Molecular Formula: C₁₈H₁₉N₃O₅
• Molecular Weight: 357.366

Synonyms:[4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid

Chemical Property of [4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid

Chemical Property:

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Technology Process of [4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid

There total 3 articles about [4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

{4-[(E)-2-(1-Methyl-5-nitro-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-acetic acid (875802-03-2) → [4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid (480994-15-8)

Guidance literature:

With formic acid; sodium dithionite; Heating;

DOI:10.1021/jm0506221

Reference yield:

3,6-dimethyl-5-nitro-1-propyl-1H-pyrimidine-2,4-dione (378794-88-8) → [4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid (480994-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dioxane / Heating

2: 60 percent / formic acid; sodium dithionite / Heating

With piperidine; formic acid; sodium dithionite; In 1,4-dioxane;

DOI:10.1021/jm0506221

Reference yield:

(4-formylphenoxy)acetic acid (22042-71-3) → [4-(3-methyl-2,4-dioxo-1-propyl-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-d]pyrimidin-6-yl)-phenoxy]-acetic acid (480994-15-8)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / dioxane / Heating

2: 60 percent / formic acid; sodium dithionite / Heating

With piperidine; formic acid; sodium dithionite; In 1,4-dioxane;

DOI:10.1021/jm0506221

upstream raw materials:

{4-[(E)-2-(1-Methyl-5-nitro-2,6-dioxo-3-propyl-1,2,3,6-tetrahydro-pyrimidin-4-yl)-vinyl]-phenoxy}-acetic acid

3,6-dimethyl-5-nitro-1-propyl-1H-pyrimidine-2,4-dione

(4-formylphenoxy)acetic acid

Downstream raw materials:

C₂₈H₃₀ClN₅O₄

C₂₈H₃₀FN₅O₄

C₂₉H₃₀F₃N₅O₄

C₃₅H₃₆N₄O₄

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