(S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Base Information

Chemical Name:(S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide
CAS No.:1380645-86-2
Molecular Formula:C₂₄H₂₂N₂O₄S
Molecular Weight:434.516
Hs Code.:

Synonyms:(S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

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Chemical Property of (S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Chemical Property:

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Technology Process of (S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

There total 5 articles about (S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 4570-41-6
1,3-benzoxazol-2-amine

: 1380646-39-8
(S)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionic acid

: 1380645-86-2
(S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 90536-66-6
4-(methylsulfonyl)phenylacetic acid

: 1380645-86-2
(S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -70 - 20 °C / Inert atmosphere

2.2: 2 h / -65 - 20 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 20 °C

With dmap; n-butyllithium; oxalyl dichloride; water; sodium hexamethyldisilazane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 1380646-38-7
(S)-4-benzyl-3-[(S)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionyl]oxazolidin-2-one

: 1380645-86-2
(S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 48 h / 20 °C

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; dichloromethane;