4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate

Base Information

• Chemical Name: 4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate
• CAS No.: 115142-19-3
• Molecular Formula: C₂₅H₃₂N₃O₁₃P
• Molecular Weight: 613.515
• Mol file: 115142-19-3.mol

Synonyms:4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate

Chemical Property of 4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate

There total 5 articles about 4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-dichlorophosphoryloxy-4-nitro-benzene (777-52-6) + 2',5'-di-O-tetrahydropyran-2-yluridine (34198-35-1) → 4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate (115142-19-3)

Guidance literature:

With pyridine; 1,2,4-Triazole; triethylamine; In acetonitrile; for 2h; Ambient temperature;

DOI:10.1021/ja00223a031

Reference yield:

3’-benzoyluridine (16667-60-0) → 4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate (115142-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: p-toluenesulfonic acid / dioxane / 1.5 h / 20 °C

1.2: NH₃ / methanol / 64 h / 4 °C

2.1: pyridine / dioxane / 2 h

With pyridine; toluene-4-sulfonic acid; In 1,4-dioxane;

DOI:10.1006/bioo.2000.1179

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → 4-nitrophenyl 2',5',-di-O-tetrahydropyranyluridine-3'-phosphate (115142-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: p-toluenesulfonic acid / dioxane / 1.5 h / 20 °C

1.2: NH₃ / methanol / 64 h / 4 °C

2.1: pyridine / dioxane / 2 h

With pyridine; toluene-4-sulfonic acid; In 1,4-dioxane;

DOI:10.1006/bioo.2000.1179

upstream raw materials:

1-dichlorophosphoryloxy-4-nitro-benzene

2',5'-di-O-tetrahydropyran-2-yluridine

3,4-dihydro-2H-pyran

uridine

Downstream raw materials:

uridine 3'-(p-nitrophenyl phosphate)