4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

Base Information

Chemical Name:4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane
CAS No.:81277-55-6
Molecular Formula:C₂₂H₂₈O₄
Molecular Weight:356.462
Hs Code.:

Synonyms:4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

Suppliers and Price of 4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

There total 21 articles about 4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 108-24-7
acetic anhydride

: 81277-65-8
1α-ethenyl-4α-hydroxy-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

: 81277-55-6
4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

Guidance literature:: In pyridine; for 14h; Ambient temperature;
DOI:10.1021/jo00133a020

Reference yield:

: 61950-54-7
(8aS)-1,1-(1,2-ethylenedioxy)-1,2,3,4,6,7,8,8a-octahydro-8a-methyl-6-oxonaphthalene

: 81277-55-6
4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

Guidance literature:: Multi-step reaction with 15 steps

1: hydrogen / Pd-C / ethanol / Ambient temperature

2: NaBH₄ / methanol / 0 °C

3: pyridine / Ambient temperature

4: 10percent HCl / acetone / Ambient temperature

5: 1.) Br₂, 2.) LiBr, Li₂CO₃ / 1.) CHCl₃, room temperature, 2.) DMF, 125 deg C

6: NaNH₂, liq. NH₃ / -78 °C

7: p-TsOH / benzene / Heating

8: 5percent NaOH, MeOH / Ambient temperature

9: 1.) Na_. liq NH₃, 2.) 10percent HCl / 1.) -78 deg C, 2.) acetone, room temperature

10: 1.) pyridinium hydrobromide perbromide, 2.) LiBr, Li₂CO₃ / 1.) CHCl₃, room temperature, 2.) DMF, 125 deg C

11: 30percent H₂O₂, 10percent NaOH / methanol / Ambient temperature

12: p-TsOH / CH₂Cl₂ / Ambient temperature

13: 1.) LiAlH₄, 2.) pyridine / 1.) THF, room temperature, 2.) room temperature

14: 1.) NaH, 2.) p-TsOH / 1.) THF, reflux, 2.) room temperature

15: pyridine / Ambient temperature

With pyridine; hydrogenchloride; methanol; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; ammonia; hydrogen; dihydrogen peroxide; bromine; pyridinium hydrobromide perbromide; sodium; lithium carbonate; sodium hydride; toluene-4-sulfonic acid; sodium amide; lithium bromide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; acetone; benzene;
DOI:10.1021/ja00400a078

Reference yield:

: 81339-52-8
(+)-(4aR,8aS)-1,2,3,4,4aβ,5,6,7,8,8a-decahydro-1,1-(1,2-ethylenedioxy)-8aβ-methyl-6-oxonaphthalene

: 81277-55-6
4α-acetoxy-1α-ethenyl-2α-<2-(4-methoxybenzocyclobutenyl)-2-oxoethyl>-1β-methylcyclohexane

Guidance literature:: Multi-step reaction with 14 steps

1: NaBH₄ / methanol / 0 °C

2: pyridine / Ambient temperature

3: 10percent HCl / acetone / Ambient temperature

4: 1.) Br₂, 2.) LiBr, Li₂CO₃ / 1.) CHCl₃, room temperature, 2.) DMF, 125 deg C

5: NaNH₂, liq. NH₃ / -78 °C

6: p-TsOH / benzene / Heating

7: 5percent NaOH, MeOH / Ambient temperature

8: 1.) Na_. liq NH₃, 2.) 10percent HCl / 1.) -78 deg C, 2.) acetone, room temperature

9: 1.) pyridinium hydrobromide perbromide, 2.) LiBr, Li₂CO₃ / 1.) CHCl₃, room temperature, 2.) DMF, 125 deg C

10: 30percent H₂O₂, 10percent NaOH / methanol / Ambient temperature

11: p-TsOH / CH₂Cl₂ / Ambient temperature

12: 1.) LiAlH₄, 2.) pyridine / 1.) THF, room temperature, 2.) room temperature

13: 1.) NaH, 2.) p-TsOH / 1.) THF, reflux, 2.) room temperature

14: pyridine / Ambient temperature

With pyridine; hydrogenchloride; methanol; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; ammonia; dihydrogen peroxide; bromine; pyridinium hydrobromide perbromide; sodium; lithium carbonate; sodium hydride; toluene-4-sulfonic acid; sodium amide; lithium bromide; In methanol; dichloromethane; acetone; benzene;
DOI:10.1021/ja00400a078