(Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

Base Information

Chemical Name:(Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide
CAS No.:1354630-17-3
Molecular Formula:C₂₂H₂₄F₃NO₂S
Molecular Weight:423.499
Hs Code.:

Synonyms:(Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

Chemical Property:

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Technology Process of (Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

There total 2 articles about (Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3108-32-5,86571-25-7
(E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one

: 212378-97-7
(R(S))-N-(1-phenylethylidene)-tert-butanesulfinamide

: 1354630-17-3
(Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

: 1354630-28-6
(Rs,S)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

Guidance literature:: (R(S))-N-(1-phenylethylidene)-tert-butanesulfinamide; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1h; Inert atmosphere;

With copper(I) bromide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1h; Inert atmosphere;

(E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 5h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.jfluchem.2011.09.002

Reference yield:

: 3108-32-5,86571-25-7
(E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one

: 212378-97-7
(R(S))-N-(1-phenylethylidene)-tert-butanesulfinamide

: 1354630-17-3
(Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

: 1354630-28-6
(Rs,S)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

: 80768-54-3,89524-14-1,108644-84-4,108644-85-5,108644-86-6,111004-15-0,122920-67-6,122920-68-7,122920-76-7,89524-18-5
(+/-)-E-1,1,1-trifluoro-4-phenylbut-3-en-2-ol

Guidance literature:: (R(S))-N-(1-phenylethylidene)-tert-butanesulfinamide; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 2h; Inert atmosphere;

(E)-1,1,1-trifluoro-4-phenyl-3-buten-2-one; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; Inert atmosphere;
DOI:10.1016/j.jfluchem.2011.09.002

Reference yield: 99.0%

: 1354630-17-3
(Rs,R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enylidene)tert-butanesulfinamide

: 1354630-30-0
(Rs,1R,3R)-N-((E)-3-hydroxy-1,5-diphenyl-3-(trifluoromethyl)pent-4-enyl)tert-butanesulfinamide

Guidance literature:: With benzo[1,3,2]dioxaborole; In tetrahydrofuran; at -10 ℃; for 24h; optical yield given as %de; stereoselective reaction;
DOI:10.1016/j.jfluchem.2011.09.002