2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt

Base Information

Chemical Name:2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt
CAS No.:1345982-86-6
Molecular Formula:C₂₅H₃₆N₂O₆S₂*H₃N
Molecular Weight:541.733
Hs Code.:

2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt

Synonyms:2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt

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Chemical Property of 2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt

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Technology Process of 2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt

There total 6 articles about 2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1345983-52-9
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine

: 4263-52-9
sodium 2-bromethanesulfonate

: 1345982-86-6
2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt

Guidance literature:: {[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine; sodium 2-bromethanesulfonate; In N,N-dimethyl-formamide; at 70 ℃;

With trifluoroacetic acid; In N,N-dimethyl-formamide; at 20 ℃;

With ammonia; In water; acetonitrile;

Reference yield: 54.0%

: 1345983-53-0
{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine trifluoroacetate salt

: 4263-52-9
sodium 2-bromethanesulfonate

: 1345982-86-6
2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt

Guidance literature:: {[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxo-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amine trifluoroacetate salt; sodium 2-bromethanesulfonate; In N,N-dimethyl-formamide; at 70 ℃;

With ammonium hydroxide; In water; acetonitrile;
DOI:10.1021/jm400459m

Reference yield:

: 1345983-39-2
(3R,5R)-3-butyl-3-ethyl-7-methoxy-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,4]thiazepin-8-yl trifluoromethanesulfonate

: 1345982-86-6
2-({[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}amino)ethanesulfonic acid ammonium salt

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; zinc / N,N-dimethyl-formamide / 0.25 h / 25 °C / Inert atmosphere

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 2068.65 Torr

3: N,N-dimethyl-formamide / 70 °C

With hydrogenchloride; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; zinc; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm400459m