tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Base Information

Chemical Name:tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate
CAS No.:1352949-31-5
Molecular Formula:C₃₄H₃₉N₃O₅
Molecular Weight:569.701
Hs Code.:

Synonyms:tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

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Chemical Property of tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

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Technology Process of tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

There total 4 articles about tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2164-34-3
2-(bromomethyl)-2,3-dihydrobenzo[1,4]dioxine

: 1352948-14-1
tert-butyl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

: 1352949-31-5
tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

: 1021-25-6
1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one

: 1352949-31-5
tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 16 h / 0 - 20 °C

2: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 2 h

4: potassium carbonate / N,N-dimethyl-formamide

With pyridine; hydrogen; sodium hexamethyldisilazane; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1352948-13-0
benzyl 3-(3-(tert-butoxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

: 1352949-31-5
tert-butyl 3-((8-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

2: potassium carbonate / N,N-dimethyl-formamide

With hydrogen; potassium carbonate; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;