(S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid

Base Information

Chemical Name:(S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid
CAS No.:342612-66-2
Molecular Formula:C₂₀H₃₆N₂O₅
Molecular Weight:384.516
Hs Code.:

Synonyms:(S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid

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Technology Process of (S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid

There total 1 articles about (S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 27527-05-5
L-cyclohexylalanine

: 3392-08-3
N-(tert-butoxy)carbonyl-L-isoleucine N-hydroxysuccinimide ester

: 342612-66-2
(S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 8h;
DOI:10.1016/S0960-894X(03)00031-3

Reference yield: 95.0%

: 342612-66-2
(S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid

: 676261-87-3
(S)-2-((2S,3S)-2-Amino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(03)00031-3

Reference yield:

: 342612-66-2
(S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-3-cyclohexyl-propionic acid

: 342612-72-0
(S)-3-[(S)-3-Cyclohexyl-2-((2S,3S)-3-methyl-2-{(S)-4-methyl-2-[(pyrazine-2-carbonyl)-amino]-pentanoylamino}-pentanoylamino)-propionylamino]-2-hydroxy-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / TFA / CH₂Cl₂

2: 90 percent / DIEA / dimethylformamide / 8 h / 0 - 20 °C

3: 95 percent / TFA / CH₂Cl₂

4: 79 percent / DIEA / dimethylformamide / 4 h / 0 - 20 °C

5: PyBOP; DIEA / dimethylformamide / 4 h / 0 - 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(03)00031-3